Structure of PDB 7vsh Chain A

Receptor sequence
>7vshA (length=1028) Species: 9606 (Homo sapiens) [Search protein sequence]
TRTVFVGNHPVQRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIF
LVQVTVDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADNEVNKSTVY
IIENAKRVRKESEKIKVGDVVEVQADETFPCDLILLSSCTTDGTCYVTTA
SLDGESNCKTHYAVRDTIALCTAESIDTLRAAIECEQPQPDLYKFVGRIN
IYSNSLEAVARSLGPENLLLKGATLKNTEKIYGVAVYTGMETKMALNYQG
KSQKRSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSTPYNDEPWYNQ
KTQKERETLKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISW
DKDFYDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCI
DGHKYKVDKNREELFLRALCLCHTVEIKTNDAVDGATESAELTYISSSPD
EIALVKGAKRYGFTFLGNRNGYMRVENQRKEIEEYELLHTLNFDAVRRRM
SVIVKTQEGDILLFCKGADSAVFPRVQNHEIELTKVHVERNAMDGYRTLC
VAFKEIAPDDYERINRQLIEAKMALQDREEKMEKVFDDIETNMNLIGATA
VEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTEL
LELTTKTIEESERKEDRLHELLIEYRKKLLHQEYGLIIDGSTLSLILNSS
QDSSSNNYKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPITLS
IGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLAHG
HLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNI
CFTSLPILAYSLLEQHINIDTLTSDPRLYMKISGNAMLQLGPFLYWTFLA
AFEGTVFFFGTYFLFQTASLEENGKVYGNWTFGTIVFTVLVFTVTLKLAL
DTRFWTWINHFVIWGSLAFYVFFSFFWGGIIWPFLKQQRMYFVFAQMLSS
VSTWLAIILLIFISLFPEILLIVLKNVR
3D structure
PDB7vsh Cryo-EM of the ATP11C flippase reconstituted in Nanodiscs shows a distended phospholipid bilayer inner membrane around transmembrane helix 2.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ALF A D409 T411 G675 K795 D820 D383 T385 G628 K732 D757
BS02 17F A M910 Q1050 M847 Q987
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0090555 phosphatidylethanolamine flippase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140346 phosphatidylserine flippase activity
Biological Process
GO:0006869 lipid transport
GO:0015914 phospholipid transport
GO:0034220 monoatomic ion transmembrane transport
GO:0045332 phospholipid translocation
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0031901 early endosome membrane
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vsh, PDBe:7vsh, PDBj:7vsh
PDBsum7vsh
PubMed34922944
UniProtQ8NB49|AT11C_HUMAN Phospholipid-transporting ATPase IG (Gene Name=ATP11C)

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