Structure of PDB 7vph Chain A

Receptor sequence
>7vphA (length=339) Species: 9606 (Homo sapiens) [Search protein sequence]
NHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDS
GQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIA
QHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCY
CADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDK
QNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNNTSAPQDIYAV
NGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHN
GNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAEELKPR
3D structure
PDB7vph Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R239 T256 F257 K258 W300 R305 T306 K307 K309 R215 T232 F233 K234 W274 R279 T280 K281 K283
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0043130 ubiquitin binding
Biological Process
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006913 nucleocytoplasmic transport
GO:0051301 cell division
GO:0060236 regulation of mitotic spindle organization
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0000922 spindle pole
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0097431 mitotic spindle pole

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vph, PDBe:7vph, PDBj:7vph
PDBsum7vph
PubMed35096974
UniProtP78406|RAE1L_HUMAN mRNA export factor RAE1 (Gene Name=RAE1)

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