Structure of PDB 7vlz Chain A

Receptor sequence

>7vlzA (length=532) Species: 1300145 (Vibrio harveyi VHJR7)

CDVEAFTSNSSNDVLNAIKTQGASCVNALFSAESRIQEAAFESGHMYNIA
KHTTDLAKAYAGGGSDELEALFLYLRAGYYAEFYNSKVSFLSWVTPAVKE
AVDAFVNNANFYENSDPHGKVLSEVIITMDSAGLQHAYLPQVTQWLTRWD
SQYAQNWYMRNAVNGVFTILFGGQWNEQFVQTIGNQTELAKALGDFALRS
SAIGASDEFMAANAGRELGRLTKYSGSASSTVKSKLTEIFAQYEMYGRGD
AIWLGAADTVSYYADCSDYGICNFESQLKGLVLSQSYTCSPTIRILSQNM
TQDQHVAACSKMGYEEGYFHTSLETGRQPVADDYNTQLQVNIFDSSDDYG
KYAGPIFNISTNNGGMYLEGDPATPGNIPNFVAYEAPYANPDHFVWNLEH
EYVHYLDGRFDLYGGFGHPTERIVWWSEGIAEYVSKENDNQAAIDTIKDG
STFTLSEIFETSYDGFDVDRIYRWGYLAVRFMFERHKDDVNQMLIETRQG
NWANYKATINQWAILYQSEFEQWQQALVLEHH

3D structure

• PDB: 7vlz Crystal structure of the collagenase unit of a Vibrio collagenase from Vibrio harveyi VHJR7
• Chain: A
• Resolution: 1.6 Å

Enzymatic activity

• Enzyme Commision number: 3.4.24.3: microbial collagenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	W234 R237 N238 F248 F286 N290 R293 S423 N439 N440 G441 G442 Y461 Y465 W473 H477 E478 H481 E505 V545 Y549	W157 R160 N161 F171 F209 N213 R216 S346 N362 N363 G364 G365 Y384 Y388 W396 H400 E401 H404 E428 V468 Y472
BS02	peptide	A	N104 F107 S108 R153 Y157 F160 Y161 I204 D207 W234 Y235 W252	N27 F30 S31 R76 Y80 F83 Y84 I127 D130 W157 Y158 W175
BS03	ZN	A	H477 H481 E505	H400 H404 E428
BS04	CA	A	E446 G485 L489 G491	E369 G408 L412 G414
BS05	CA	A	N376 D421 E462	N299 D344 E385
BS06	CA	A	T523 D526 S528	T446 D449 S451

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:7vlz, PDBe:7vlz, PDBj:7vlz
• PDBsum: 7vlz
• UniProt: A0A8B3DGT3