Structure of PDB 7vkn Chain A

Receptor sequence
>7vknA (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
GSGIRVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKAL
KEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRD
LNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHF
VHRDLATRNCLVGQGLVVKIGDFGMRDIYSTDYYRVGGRTMLPIRWMPPE
SILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELE
RPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDV
3D structure
PDB7vkn Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7GI A V524 A542 M592 R595 N655 L657 G667 R673 V28 A46 M96 R99 N159 L161 G171 R176 BindingDB: IC50=0.400000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vkn, PDBe:7vkn, PDBj:7vkn
PDBsum7vkn
PubMed34625502
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

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