Structure of PDB 7vka Chain A

Receptor sequence
>7vkaA (length=595) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
SDESLAEKNKNKLQFIEDVTTNADDVQRRVLEEILSRNADVEYLKRHGLE
GRTDRETFKHIMPVVTYEDIQPEINRIANGDKSQVLCSNPISEFLTSSGT
SGGERKLMPTIEEELDRRSLLYSLLMPVMDQFVPGLDKGKGMYFLFIKSE
SKTPGGLPARPVLTSYYKSSHFKNRPYDPYTNYTSPNQTILCSDSYQSMY
SQMLCGLCQHKEVLRVGAVFASGFIRAIKFLEKHWPELARDIRTGTLSSE
ITDSSVREAVGEILKPDPKLADFVESECRKTSWQGIITRLWPNTKYVDVI
VTGTMSQYIPTLDYYSNGLPLVCTMYASSECYFGVNLRPLCKPSEVSYTL
IPNMAYFEFLPVHRNSGVTSSISLPKALKEQQELVDLVDVKLGQEYELVV
TTYAGLYRYRVGDVLSVAGFKNNAPQFSFICRKNVVLSIDSDKTDEVELQ
NAVKNAVTHLVPFDASLSEYTSYADTSSIPGHYVLFWELCLNGNTPIPPS
VFEDCCLTIEESLNSVYRQGRVSDKSIGPLEIKMVESGTFDKLMDYAISL
GASINQYKTPRCVKFAPIIELLNSRVVDSYFSPKCPKWSPGHKQW
3D structure
PDB7vka Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation.
ChainA
Resolution2.401 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A S109 S110 I312 T314 Y338 A339 S340 S341 Y360 D427 F443 R446 S97 S98 I300 T302 Y326 A327 S328 S329 Y348 D413 F429 R432
BS02 7IS A Y134 Y178 Y195 I312 M337 A339 S340 Y122 Y166 Y183 I300 M325 A327 S328
Gene Ontology
Molecular Function
GO:0010279 indole-3-acetic acid amido synthetase activity
GO:0016874 ligase activity
Biological Process
GO:0009733 response to auxin
GO:0009734 auxin-activated signaling pathway
GO:0009826 unidimensional cell growth
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:7vka, PDBe:7vka, PDBj:7vka
PDBsum7vka
PubMed36454752
UniProtQ9LSQ4|GH36_ARATH Indole-3-acetic acid-amido synthetase GH3.6 (Gene Name=GH3.6)

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