Structure of PDB 7vjl Chain A

Receptor sequence
>7vjlA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
LPLDPLWEFPRDRLVLGKPLGEGGQVVRAEAFGMDPARPDQASTVAVKML
DNASDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNL
REFLRARRPPGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVT
EDNVMKIADFGPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPY
PGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLV
EALDKVLLAVSEE
3D structure
PDB7vjl Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design.
ChainA
Resolution2.90017 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7IF A L473 R483 T499 V500 A501 K503 C552 A553 A554 L619 L20 R28 T44 V45 A46 K48 C94 A95 A96 L148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7vjl, PDBe:7vjl, PDBj:7vjl
PDBsum7vjl
PubMed34670167
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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