Structure of PDB 7vhy Chain A

Receptor sequence
>7vhyA (length=437) Species: 9606 (Homo sapiens) [Search protein sequence]
YCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGE
SVSLTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAG
FVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESG
EVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGV
DLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILI
GYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWFKK
MLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKE
SGGSGSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMD
GRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQS
3D structure
PDB7vhy Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1163 H1255 C1258 C2 H86 C89
BS02 ZN A C1250 C1272 C1275 C81 C103 C106
BS03 ZN A C1177 C1183 C1201 C16 C22 C40
BS04 6QI A L1398 D1399 S1400 Y1414 P1440 D1444 D1445 H1451 Q1455 I1457 P1458 W1466 L229 D230 S231 Y245 P271 D275 D276 H282 Q286 I288 P289 W297
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7vhy, PDBe:7vhy, PDBj:7vhy
PDBsum7vhy
PubMed35413416
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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