Structure of PDB 7vhf Chain A

Receptor sequence
>7vhfA (length=283) Species: 562 (Escherichia coli) [Search protein sequence]
REFTIDFSTQQSYVSSLNSIRTEISTPLEHISQGTTSVSVINHTPPGSYF
AVDIRGLDVYQARFDHLRLIIEQNNLYVAGFVNTATNTFYRFSDFTHISV
PGVTTVSMTTDSSYTTLQRVAALERSGMQISRHSLVSSYLALMEFSGNTM
TRDASRAVLRFVTVTAEALRFRQIQREFRQALSETAPVYTMTPGDVDLTL
NWGRISNVLPEYRGEDGVRVGRISFNNISAILGTVAVILNCHQPECQITG
DRPVIKINNTLWESNTAAAFLNRKSQFLYTTGK
3D structure
PDB7vhf A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y77 V78 D94 F95 S112 S113 Y114 E167 R170 T199 Y77 V78 D94 F95 S112 S113 Y114 E167 R170 T199
BS02 1PS A V78 S112 V78 S112
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0030598 rRNA N-glycosylase activity
GO:0090729 toxin activity
Biological Process
GO:0017148 negative regulation of translation
GO:0035821 modulation of process of another organism

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7vhf, PDBe:7vhf, PDBj:7vhf
PDBsum7vhf
PubMed35794188
UniProtQ7DI68

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