Structure of PDB 7vgm Chain A

Receptor sequence

>7vgmA (length=571) Species: 226900 (Bacillus cereus ATCC 14579)

KKTEIPSHLKPFVSTQHYDQYTPVNHAVWRYIMRQNHSFLKDVAHPAYVN
GLQSSGINIDAIPKVEEMNECLAPSGWGAVTIDGLIPGVAFFDFQGHGLL
PIATDIRKVENIEYTPAPDIVHEAAGHAPILLDPTYAKYVKRFGQIGAKA
FSTKEEHDAFEAVRTLTIVKESPTSTPDEVKAAENAVIEKQNLVSGLSEA
EQISRLFWWTVEYGLIGNIDDPKIYGAGLLSSVGESKHCLTDAVEKVPFS
IEACIGTTYDVTKMQPQLFVCESFEELTDALETFSKTMAFKTGGKEGLEK
AIRSENYATAELNSGLQITGTFSETIENDAGELIYMRTNSPTALALHNKQ
LANHSTSVHSDGFGTPIGLLTENIALENCTDEQLQSLGITIGTIAEFTFA
SGIHVKGTVTDIVKNDKKIALISFIDCTVTYNARVLFDASWGAFDMAVGS
QITSVFPGAADAAAFFPMDEEVHEIPAPLVLNELERMYQTVRDIRSEGIL
HDAHIDQLIAIQEVLNKFYAKEWLLRLEVLELLLEHNKGHETSAALLHQL
STFTTDEAVTRLINNGLALLP

3D structure

• PDB: 7vgm Structural studies of a novel auxiliary-domain-containing phenylalanine hydroxylase from Bacillus cereus ATCC 14579.
• Chain: A
• Resolution: 2.27 Å

Enzymatic activity

• Enzyme Commision number: 1.14.16.1: phenylalanine 4-monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FE	A	H124 H129 E214	H122 H127 E212

Gene Ontology

Molecular Function

• GO:0004497 monooxygenase activity
• GO:0004505 phenylalanine 4-monooxygenase activity
• GO:0005506 iron ion binding
• GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
• GO:0046872 metal ion binding

Biological Process

• GO:0009072 aromatic amino acid metabolic process
• GO:0019293 tyrosine biosynthetic process, by oxidation of phenylalanine

External links

• PDB: RCSB:7vgm, PDBe:7vgm, PDBj:7vgm
• PDBsum: 7vgm
• PubMed: 35503207
• UniProt: Q818B4