Structure of PDB 7vdt Chain A

Receptor sequence

>7vdtA (length=617) Species: 9606 (Homo sapiens)

KLIDQKKDKRLAYLLQQTDEYYAVAHAVTERVDKQSALMVNGVLKQYQIK
GLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIV
PLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTY
EYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLT
GTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEE
TILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRH
MQAKGVLLTDGSGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGG
IVQGLDLYRASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAY
RGFKYLRLDGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSA
DTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAA
KYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDET
VNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKEK
MFGRGSRHRKEVDYSDS

3D structure

• PDB: 7vdt Structure of human chromatin-remodelling PBAF complex bound to a nucleosome.
• Chain: A
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R885 K887 C891 K892 H900 W1178	R175 K177 C181 K182 H190 W460
BS02	dna	A	L812 R841 E861 Y862 K865 M1036 N1037 M1105 T1106 G1128 R1135 S1155 R1157 A1158	L102 R131 E151 Y152 K155 M318 N319 M387 T388 G410 R417 S437 R439 A440
BS03	BEF	A	M781 R1189 R1192	M71 R471 R474
BS04	ADP	A	Q758 G782 G784 K785 T786 I787 W825 N1164 R1192	Q48 G72 G74 K75 T76 I77 W115 N446 R474

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0042393 histone binding
• GO:0140658 ATP-dependent chromatin remodeler activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:7vdt, PDBe:7vdt, PDBj:7vdt
• PDBsum: 7vdt
• PubMed: 35477757
• UniProt: P51532|SMCA4_HUMAN Transcription activator BRG1 (Gene Name=SMARCA4)