Structure of PDB 7vc5 Chain A

Receptor sequence
>7vc5A (length=485) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
AMVTAKKDENFSEWYTQAIVRSEMIEYYDISGCYIMRPWAFHIWEKVQRF
FDDEIKKMGVENSYFPMFVSRHKLEKFSPEVAWVTHYGDSPLPEKIAIRP
TSETIMYPAYAKWIRSHRDLPLKLNQWCSVVRWEFKQPTPFLRTREFLWQ
EGHTAHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGK
KTTTVEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHKRLVHQTS
WGCTTRSLGVMIMTHGDDKGLVIPPRVASVQVVIIPILFKDENTGEILGK
CRELKTMLEKADIRVRIDDRSNYTPGWKYNHWEVKGVPLRLELGPKDLAK
GTARVVRRDTGEAYQISWADLAPKLLELMEGIQRSLFEKAKARLHEGIEK
ISTFDEVMPALNRKHLVLAPWCEDPESEEQIKKETQKLSEIQAIEAGGAM
KTLCIPFDQPPMPEGTKCFYTGKPAKRWTLWGRSY
3D structure
PDB7vc5 TgPRS with double inhibitors
ChainA
Resolution1.612 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1TI A E472 K474 Q475 P476 L480 R481 T482 F485 W487 Q555 A556 A557 G590 T592 R594 E134 K136 Q137 P138 L142 R143 T144 F147 W149 Q217 A218 A219 G252 T254 R256
BS02 9SF A F415 P438 T439 E441 R470 W487 F534 H560 W589 F77 P100 T101 E103 R132 W149 F196 H222 W251
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vc5, PDBe:7vc5, PDBj:7vc5
PDBsum7vc5
PubMed
UniProtA0A7J6JUK2

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