Structure of PDB 7vc2 Chain A

Receptor sequence
>7vc2A (length=478) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
AMVTAKKDENFSEWYTQAIVRSEMIEYYDISGCYIMRPWAFHIWEKVQRF
FDDEIKKMGVENSYFPMFVSRHKLEKPEVAWVTHYGDSPLPEKIAIRPTS
ETIMYPAYAKWIRSHRDLPLKLNQWCSVVRWEFKQPTPFLRTREFLWQEG
HTAHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGKKT
TTVEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHKRLVHQTSWG
CTTRSLGVMIMTHGDDKGLVIPPRVASVQVVIIPILFKDENTGEILGKCR
ELKTMLEKADIRVRIDDRSNYTPGWKYNHWEVKGVPLRLELGPKDLAKGT
ARVVRRDTGEAYQISWADLAPKLLELMEGIQRSLFEKAKARLHEGIEKIS
TFDEVMPALNRKHLVLAPWCEDPESEEQIKKETQKLSEMTGAMKTLCIPF
DQPPMPEGTKCFYTGKPAKRWTLWGRSY
3D structure
PDB7vc2 Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
ChainA
Resolution2.096 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1UI A E472 K474 Q475 P476 L480 R481 T482 R483 F485 W487 Q555 A557 T592 R594 E132 K134 Q135 P136 L140 R141 T142 R143 F145 W147 Q215 A217 T252 R254
BS02 PRO A T439 E441 W487 E489 F534 H560 S588 W589 G590 T99 E101 W147 E149 F194 H220 S248 W249 G250
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7vc2, PDBe:7vc2, PDBj:7vc2
PDBsum7vc2
PubMed36854028
UniProtA0A7J6JUK2

[Back to BioLiP]