Structure of PDB 7v9q Chain A

Receptor sequence

>7v9qA (length=859) Species: 405948 (Saccharopolyspora erythraea NRRL 2338)

APPNLTREQAEQRAALLEVQSYAIELDLSAGAGGPEVETFGSTTTVRFRS
ATPGAESWIDLVAARVRSAVLNGVELDVSDYDESTGIRLPELAADNELVV
HADCQYTNTGEGLHRFIDPVDGGVYLYSQFETADAKRMFTCFDQPDLKAT
YQITVTAPQDWKVISNAAGEVTDTGEGTRRHVFDTTKPMSTYLVALVAGP
YAEWRDVFPGDDGQDEIPLGIYCRASLAEHLDAERLFIETKQGFGFFHKA
FGVPYPFGKYDQCFVPEFNAGAMENAGCVTFLEDYVFRSRVTGYLYERRS
ETVLHEMAHMWFGDLVTMRWWDDLWLNESFATWASVLAQVGATQYTNAWT
TFASVEKSWAYRQDQLPSTHPVAADIPDLQAVEVNFDGITYAKGASVLKQ
LVAYVGLENFLAGLKVYFDRHAWGNATLDDLLVALEEASGRDLSWWSAQW
LQTTGLNMLRPKLAIDDEGRFTSFSVLQSPARPGAGEHRTHRLAIGIYDD
DPATGELVRTHRVELDVTGERTEVPDLVGVHRGKLVLVNDDDLTYCTMRL
DPQSLATLIDRIADIQESLPRALCWSTAWEMTREAELKARDFVSLVLGSS
PTTGIGAESEIGVVQRVLLQTQTALASYADPAWQPEGWRRFAGRLLELAR
AAEPGSDHQLAFVNSLAGSVLGEEQISAMRGWLDGTAPLEGLTVDTDLRW
GLLQALVAHGAAGEAEIDAELERDQTATGRRRAERARSLIPTPEAKEKAW
QRAVHDDQLPNAISDAIISGFQHPGQRELLASYVRRYFDEIDEVWHRRSS
ERAQPTVIGLFPSWAVDEDTVAVADRWLEGEHAPALRRLVSEGRAGIVRA
LAAREFDRS

3D structure

• PDB: 7v9q Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases.
• Chain: A
• Resolution: 2.67 Å

Enzymatic activity

• Enzyme Commision number: 3.4.11.2: membrane alanyl aminopeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H306 H310 E329	H305 H309 E328

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0042277 peptide binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0043171 peptide catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7v9q, PDBe:7v9q, PDBj:7v9q
• PDBsum: 7v9q
• PubMed: 35513512
• UniProt: A4F9D7