Structure of PDB 7v9d Chain A

Receptor sequence
>7v9dA (length=486) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
AITSKKIENFSDWYTQVIVKSELIEYYDISGCYILRPAAYYIWECVQAFF
NKEIKKLNVENSYFPLFVTKNKLEKEKNHIEGFSPEVAWVTKYGDSNLPE
EIAIRPTSETIMYSVFPKWIRSYRDLPLKLNQWNTVVRWEFKQPTPFIRT
REFLWQEGHTAHKNEEEAVKLVFDILDLYRRWYEEYLAVPIIKGIKSEGE
KFGGANFTSTAEAFISENGRAIQAATSHYLGTNFAKMFKIEFEDENEVKQ
YVHQTSWGCTTRSIGIMIMTHGDDKGLVLPPNVSKYKVVIVPIFDENAIH
SYCKDIEKILKNAQINCVYDDRASYSPGYKFNHWELRGIPIRIEVGPKDL
QNNSCVIVRRDNNEKCNVKKESVLLETQQMLVDIHKNLFLKAKKKLDDSI
VQVTSFSEVMNALNKKKMVLAPWCEDIATEEEIKKETQRLSLNETTLSGA
MKPLCIPLDQPPMPPNMKCFWSGKPAKRWCLFGRSY
3D structure
PDB7v9d Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with inhibitor L95 and azetidine
ChainA
Resolution1.937 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JE6 A R390 E392 K394 Q395 I400 R401 T402 F405 W407 Q475 A477 T512 R514 R138 E140 K142 Q143 I148 R149 T150 F153 W155 Q223 A225 T260 R262
BS02 02A A T359 E361 W407 F454 H480 S508 W509 T107 E109 W155 F202 H228 S256 W257
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7v9d, PDBe:7v9d, PDBj:7v9d
PDBsum7v9d
PubMed
UniProtQ8I5R7|SYP_PLAF7 Proline--tRNA ligase (Gene Name=proRS)

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