Structure of PDB 7v6z Chain A

Receptor sequence
>7v6zA (length=1008) Species: 10090 (Mus musculus) [Search protein sequence]
LHRPSYCDAAFALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCG
KFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGE
EAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKL
EHLCYKSGEYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLR
WTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCP
ATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLV
SAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILEAWQRTYVE
VVHQSVAPNSTQKVLPFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACL
TMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPF
LALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISN
VTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRRED
RRLDIFCKWTLSSFAEKHYAPFLLKPKAKVVVILLFLGLLGVSLYGTTRV
RDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYD
LHKSFSNVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPN
NYKNGSDDGVLAYKLLVQTGSRDISQLTKQRLVDADGIINPSAFYIYLTA
WVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFP
FYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQYISLR
HWLLLSISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIG
IKLSAVPVVILIASVGIGVEFTAHVALAFLTAIGDKNHRAMLALEHMFAP
VLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLL
SFFGPCPE
3D structure
PDB7v6z Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae.
ChainA
Resolution3.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A G193 E194 L316 S317 G158 E159 L275 S276
Gene Ontology
Molecular Function
GO:0008158 hedgehog receptor activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:7v6z, PDBe:7v6z, PDBj:7v6z
PDBsum7v6z
PubMed34174188
UniProtQ61115|PTC1_MOUSE Protein patched homolog 1 (Gene Name=Ptch1)

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