Structure of PDB 7v6y Chain A

Receptor sequence
>7v6yA (length=990) Species: 10090 (Mus musculus) [Search protein sequence]
KAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLET
NVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTE
ALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELYMDQIIEYLYPCLI
ITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSW
EEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQ
GLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRG
YDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLPFTTTTLD
DILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVA
LSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQN
KRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAA
VVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTKWTLSSFAEKHYA
PFLLKPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI
AAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHKSFSNVKYVMLEENKQLP
QMWLHYFRDWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTG
SRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANI
RPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI
EKVRVICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLSISVVLACTFL
VCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVG
IGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLA
GSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFGPC
3D structure
PDB7v6y Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A S192 L195 P211 V273 M321 S133 L136 P147 V209 M257
BS02 CLR A L102 A105 V423 Y432 L471 T486 L43 A46 V359 Y368 L407 T422
BS03 5VI A V111 E112 F408 L413 F781 F786 Y787 Y999 F1003 W1004 V52 E53 F344 L349 F604 F609 Y610 Y822 F826 W827
Gene Ontology
Molecular Function
GO:0008158 hedgehog receptor activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7v6y, PDBe:7v6y, PDBj:7v6y
PDBsum7v6y
PubMed34174188
UniProtQ61115|PTC1_MOUSE Protein patched homolog 1 (Gene Name=Ptch1)

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