Structure of PDB 7v3z Chain A

Receptor sequence

>7v3zA (length=431) Species: 882,9606

FMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRP
SYLFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFT
ASVGSLFLAAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLP
LLGWNCEKLQSVCSDIFPHIDKTYLMFWIGVVSVLLLFIVYAYMYILWKA
HSHAVAKALIVYGSTTGNTEYTAETIARELADAGYEVDSRDAASVEAGGL
FEGFDLVLLGCSTWGDDSIELQDDFIPLFDSLEETGAQGRKVACFGCGDS
SWEYFCGAVDAIEEKLKNLGAEIVQDGLRIDGDPRAARDDIVGWAHDVRG
AIRMDIELAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCS
MLCLLNSTVNPIIYALRSKDLRHAFRSMFPS

3D structure

• PDB: 7v3z A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1.
• Chain: A
• Resolution: 3.29 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	9GF	A	F170 S173 F174 F177 K192 L193 V196 I267 F268 Y275 W279 F501	F69 S72 F73 F76 K91 L92 V95 I166 F167 Y174 W178 F396
BS02	CLR	A	L154 S158 F237 W241 I245	L53 S57 F136 W140 I144
BS03	FMN	A	S315 T316 T317 N319 T320 S363 T364 W365 G366 C398 G399 D400 W403 Y405 G433	S214 T215 T216 N218 T219 S262 T263 W264 G265 C297 G298 D299 W302 Y304 G332

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004949 cannabinoid receptor activity
• GO:0009055 electron transfer activity
• GO:0010181 FMN binding

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7v3z, PDBe:7v3z, PDBj:7v3z
• PDBsum: 7v3z
• PubMed: 34596399
• UniProt: P00323|FLAV_NITV2 Flavodoxin (Gene Name=DVU_2680);
  P21554|CNR1_HUMAN Cannabinoid receptor 1 (Gene Name=CNR1)