Structure of PDB 7v2z Chain A

Receptor sequence

>7v2zA (length=440) Species: 64320 (Zika virus)

CFEPSMLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKTRLRTVILAPTRV
VAAEMEEALRGLPVRYMTTAVNVTHSGTEIVDLMCHATFTSRLLQPIRVP
NYNLYIMDEAHFTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFP
DSNSPIMDTEVEVPERAWSSGFDWVTDHSGKTVWFVPSVRNGNEIAACLT
KAGKRVIQLSRKTFETEFQKTKHQEWDFVVTTDISEMGANFKADRVIDSR
RCLKPVILDGERVILAGPMPVTHASAAQRRGRIGRNPNKPGDEYLYGGGC
AETDEDHAHWLEARMLLDNIYLQDGLIASLYRPEADKVAAIEGEFKLRTE
QRKTFVELMKRGDLPVWLAYQVASAGITYTDRRWCFDGTTNNTIMEDSVP
AEVWTRHGEKRVLKPRWMDARVCSDHAALKSFKEFAAGKR

3D structure

• PDB: 7v2z Structural Basis of Zika Virus Helicase in RNA Unwinding and ATP Hydrolysis.
• Chain: A
• Resolution: 2.10102 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	T225 R226 T245 C262 A264 T265 D291 S365 V366 S387 R388 T409 D410 I411 P432 L442 D540 R598	T48 R49 T68 C85 A87 T88 D114 S188 V189 S210 R211 T232 D233 I234 P255 L265 D363 R421
BS02	ATP	A	P196 G197 A198 G199 K200 T201 R202 E286 Q455 R459 R462	P19 G20 A21 G22 K23 T24 R25 E109 Q278 R282 R285

Gene Ontology

Molecular Function

• GO:0004386 helicase activity
• GO:0005524 ATP binding

External links

• PDB: RCSB:7v2z, PDBe:7v2z, PDBj:7v2z
• PDBsum: 7v2z
• PubMed: 34904824
• UniProt: A0A024B7W1|POLG_ZIKVF Genome polyprotein