Structure of PDB 7v29 Chain A

Receptor sequence
>7v29A (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVK
MLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECA
AKGNLREFLRARRPPSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRK
CIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMA
PEALFDEVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHR
MDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV
3D structure
PDB7v29 Structure-based design of a dual-warhead covalent inhibitor of FGFR4.
ChainA
Resolution1.983 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5JR A L473 G474 G476 C477 V481 R483 K503 E520 M524 V550 E551 C552 A553 G556 L619 A629 D630 F631 L20 G21 G23 C24 V28 R30 K50 E67 M71 V97 E98 C99 A100 G103 L162 A172 D173 F174
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7v29, PDBe:7v29, PDBj:7v29
PDBsum7v29
PubMed36697897
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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