Structure of PDB 7v1h Chain A

Receptor sequence
>7v1hA (length=259) Species: 12542 (Omsk hemorrhagic fever virus) [Search protein sequence]
MTLGDLWKRRLNNCTKEEFFAYRRTGILETERDKARELLRKGETNMGLAV
SRGTAKLAWLEERGYVNLKGEVVDLGCGRGGWSYYAASRPAVMGVKAYTI
GGKGHEAPKMVTSLGWNLIKFRAGMDVFTMQPHRADTVMCDIGESSPDAA
IEGERTRKVILLMEQWKNRNPSASCVFKVLAPYRPEVIEALHRFQLQWGG
GLVRTPFSRNSTHEMYYSTAISGNIVNSVNVQSRKLLARFGDQRGPIRVP
EMDLGVGTR
3D structure
PDB7v1h Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MGP A K13 L16 N17 C19 K21 F24 R28 S151 P152 S216 K8 L11 N12 C14 K16 F19 R23 S146 P147 S211
BS02 SAM A S56 G58 G81 G86 W87 T104 I105 H110 E111 M130 D131 V132 F133 D146 I147 S51 G53 G76 G81 W82 T99 I100 H105 E106 M125 D126 V127 F128 D141 I142
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7v1h, PDBe:7v1h, PDBj:7v1h
PDBsum7v1h
PubMed35758665
UniProtC4TPE0

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