Structure of PDB 7v15 Chain A

Receptor sequence
>7v15A (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE
SPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLE
TTVNYTDSQRPISLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKI
PLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVW
HLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQ
3D structure
PDB7v15 Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
ChainA
Resolution1.679 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OSX A H431 Y521 A570 C571 K572 G573 S575 T593 S594 W595 G596 G598 C599 V607 H44 Y134 A183 C184 K185 G186 S188 T206 S207 W208 G209 G211 C212 V220
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7v15, PDBe:7v15, PDBj:7v15
PDBsum7v15
PubMed35862732
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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