Structure of PDB 7uzp Chain A

Receptor sequence
>7uzpA (length=101) Species: 9606 (Homo sapiens) [Search protein sequence]
DVMTKEEQIFLLHRAQAQCEKRLKEVLQRPAGRPCLPEWDHILCWPLGAP
GEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKF
L
3D structure
PDB7uzp Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo.
ChainA
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V31 M32 K34 L41 D69 I71 Y92 D93 V113 R118 T119 W120 A121 Y123 F129 L130 V2 M3 K5 L12 D40 I42 Y63 D64 V84 R89 T90 W91 A92 Y94 F100 L101
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uzp, PDBe:7uzp, PDBj:7uzp
PDBsum7uzp
PubMed36409914
UniProtQ03431|PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (Gene Name=PTH1R)

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