Structure of PDB 7uyz Chain A

Receptor sequence

>7uyzA (length=353) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFGNPLSHFLE
GEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEE
ISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAK
DGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKY
LLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLL
AFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPI
FDK

3D structure

PDB

7uyz Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG

Chain

Resolution

2.49 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R158 L159 K160 R161 H203 E386 K395	R10 L11 K12 R13 H55 E233 K242
BS02	dna	A	R161 S165 A168 Y200 Y201 K372	R13 S17 A20 Y52 Y53 K219
BS03	dna	A	T334 K335 T338	T181 K182 T185
BS04	dna	A	R222 K315 G316 R342	R74 K162 G163 R189
BS05	MG	A	E211 D213	E63 D65
BS06	MG	A	E211 D213 D307	E63 D65 D154
BS07	ZN	A	H378 C384 C385 C392	H225 C231 C232 C239
BS08	G	A	E211 K288 C419 S420	E63 K135 C266 S267
BS09	GTP	A	G198 S199 E211 D213 K402 C419 S420 Y421	G50 S51 E63 D65 K249 C266 S267 Y268

External links

PDB	RCSB:7uyz, PDBe:7uyz, PDBj:7uyz
PDBsum	7uyz
PubMed
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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