Structure of PDB 7uyv Chain A

Receptor sequence
>7uyvA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPD
QQRDFQREIQILKALHSDFIVKYRGVSYQSLRLVMEYLPSGCLRDFLQRH
RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIAD
FGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVL
YELFTYCDKSCSPSAEFLRMMVPALSRLLELLEEGQRLPAPPACPAEVHE
LMKLCWAPSPQDRPSFSALGPQLDMLWS
3D structure
PDB7uyv Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OV5 A L828 G829 A853 Y904 L905 G908 L956 D967 L15 G16 A40 Y87 L88 G91 L139 D150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7uyv, PDBe:7uyv, PDBj:7uyv
PDBsum7uyv
PubMed35842205
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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