Structure of PDB 7uyu Chain A

Receptor sequence
>7uyuA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
PTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALRSGWKQ
EIDILRTLYHEHIIKYKGCCEDLQLVMEYVPLGSLRDYLPRHSIGLAQLL
LFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPHE
YYRVSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKF
LELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASF
RPTFENLIPILKTVHEKYQ
3D structure
PDB7uyu Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OV0 A R901 L903 G904 E905 V911 A928 M978 Y980 V981 P982 G984 D988 L1030 R13 L15 G16 E17 V23 A40 M77 Y79 V80 P81 G83 D87 L129
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7uyu, PDBe:7uyu, PDBj:7uyu
PDBsum7uyu
PubMed35842205
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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