Structure of PDB 7uys Chain A

Receptor sequence
>7uysA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
TVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKCGPQHR
SGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLP
RHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGD
FGLAKAVPHEYYRVREDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELL
THCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVY
HLMKNCWETEASFRPTFENLIPILKTVHEKYQ
3D structure
PDB7uys Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OVC A L903 G904 E905 V911 A928 M978 E979 Y980 V981 G984 L1030 L14 G15 E16 V22 A39 M87 E88 Y89 V90 G93 L139
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7uys, PDBe:7uys, PDBj:7uys
PDBsum7uys
PubMed35842205
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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