Structure of PDB 7uyq Chain A

Receptor sequence

>7uyqA (length=347) Species: 10090 (Mus musculus) [Search protein sequence]

PDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLN
TGSYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFPLSHFLE
GEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEE
ISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKFQG
ETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKK
EFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECL
RTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL

3D structure

PDB

7uyq Structure of GTP binds to Cyclic GMP AMP synthase (cGAS) through Mg coordination

Chain

Resolution

2.57 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R158 L159 K160 R161 H203 E386	R12 L13 K14 R15 H57 E226
BS02	dna	A	R161 S165 A168 N196 Y200 Y201 K372	R15 S19 A22 N50 Y54 Y55 K212
BS03	dna	A	T334 K335 T338	T181 K182 T185
BS04	dna	A	K315 G316 R342	K162 G163 R189
BS05	GTP	A	T197 M215 S291 P292 D307 I309 R364 S366 S368	T51 M69 S138 P139 D154 I156 R204 S206 S208
BS06	GTP	A	G198 S199 Q211 N213 R364 S368 E371 K402 S420 Y421	G52 S53 Q65 N67 R204 S208 E211 K242 S260 Y261
BS07	MG	A	Q211 N213	Q65 N67
BS08	ZN	A	H378 C384 C385 C392	H218 C224 C225 C232

External links

PDB	RCSB:7uyq, PDBe:7uyq, PDBj:7uyq
PDBsum	7uyq
PubMed
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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