BioLiP

>7uxcA (length=2188) Species: 9606 (Homo sapiens) [Search protein sequence]

VSVLQQFASGLETRAKAAKELQHYVTRFYDQLNHHIFELVSSSDANERKG
GILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLAM
AGDTFTAEYVEFEVKRALEWLGEGRRHAAVLVLRELAISVPTFFFQQVQP
FFDNIFVAVWDPKQAIREGAVAALRACLILTTQRWYRHTFEEAEKGFRDD
RIHGALLILNELVRISSMEGERLREEMEEITESRCCRDLMEEKFDQVCQW
VLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKK
EKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAAATVFTCISMLARAM
GPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKML
SLVLMVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAA
RTCSRLLTPSVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERF
DAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKM
LIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKL
KDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKR
QVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRV
LGLLGALDPYKHKVNIEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSH
HHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQL
GMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGE
FKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLP
PIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQS
PELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRI
VKGYTLSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCW
ALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAEVT
QTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEF
QKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLH
EWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLV
NDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQ
DLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQ
YKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWL
KYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNM
WKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKL
GEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHY
KHQNQARDEKKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRV
LTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRL
IHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLV
QQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHA
MMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYH
VFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSI
APSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVN
TLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREK
KKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLK
SPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHI
DFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEV
LREHKDSVMAVLEAFVYDPLLNWRLMDTNTALNKKAIQIINRVRDKLTGR
DFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

BS01

IHP

K1655 S1658 Y1698 K1702 R1749 K1753 K1788

K1401 S1404 Y1444 K1448 R1495 K1499 K1534

Molecular Function

GO:0001002

RNA polymerase III type 1 promoter sequence-specific DNA binding

GO:0001003

RNA polymerase III type 2 promoter sequence-specific DNA binding

GO:0001006

RNA polymerase III type 3 promoter sequence-specific DNA binding

GO:0001156

TFIIIC-class transcription factor complex binding

GO:0004672

protein kinase activity

GO:0004674

protein serine/threonine kinase activity

protein binding

ATP binding

kinase activity

identical protein binding

GO:0043022

ribosome binding

GO:0044024

histone H2AS1 kinase activity

GO:0044877

protein-containing complex binding

GO:0051219

phosphoprotein binding

GO:0106310

protein serine kinase activity

	Biological Process
GO:0001558	regulation of cell growth
GO:0002296	T-helper 1 cell lineage commitment
GO:0003007	heart morphogenesis
GO:0003179	heart valve morphogenesis
GO:0006112	energy reserve metabolic process
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006338	chromatin remodeling
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0006974	DNA damage response
GO:0007010	cytoskeleton organization
GO:0007040	lysosome organization
GO:0007281	germ cell development
GO:0007584	response to nutrient
GO:0008361	regulation of cell size
GO:0009267	cellular response to starvation
GO:0009408	response to heat
GO:0009791	post-embryonic development
GO:0010506	regulation of autophagy
GO:0010507	negative regulation of autophagy
GO:0010592	positive regulation of lamellipodium assembly
GO:0010628	positive regulation of gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010831	positive regulation of myotube differentiation
GO:0016236	macroautophagy
GO:0016241	regulation of macroautophagy
GO:0016242	negative regulation of macroautophagy
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0019219	regulation of nucleobase-containing compound metabolic process
GO:0019228	neuronal action potential
GO:0030030	cell projection organization
GO:0030163	protein catabolic process
GO:0030307	positive regulation of cell growth
GO:0030838	positive regulation of actin filament polymerization
GO:0031295	T cell costimulation
GO:0031529	ruffle organization
GO:0031641	regulation of myelination
GO:0031648	protein destabilization
GO:0031667	response to nutrient levels
GO:0031669	cellular response to nutrient levels
GO:0031670	cellular response to nutrient
GO:0031929	TOR signaling
GO:0032868	response to insulin
GO:0032869	cellular response to insulin stimulus
GO:0032956	regulation of actin cytoskeleton organization
GO:0033173	calcineurin-NFAT signaling cascade
GO:0034198	cellular response to amino acid starvation
GO:0035264	multicellular organism growth
GO:0038202	TORC1 signaling
GO:0042752	regulation of circadian rhythm
GO:0043066	negative regulation of apoptotic process
GO:0043200	response to amino acid
GO:0043276	anoikis
GO:0045670	regulation of osteoclast differentiation
GO:0045727	positive regulation of translation
GO:0045792	negative regulation of cell size
GO:0045821	positive regulation of glycolytic process
GO:0045945	positive regulation of transcription by RNA polymerase III
GO:0045948	positive regulation of translational initiation
GO:0046777	protein autophosphorylation
GO:0046889	positive regulation of lipid biosynthetic process
GO:0048266	behavioral response to pain
GO:0048511	rhythmic process
GO:0048709	oligodendrocyte differentiation
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0048738	cardiac muscle tissue development
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050882	voluntary musculoskeletal movement
GO:0051128	regulation of cellular component organization
GO:0051247	positive regulation of protein metabolic process
GO:0051496	positive regulation of stress fiber assembly
GO:0051549	positive regulation of keratinocyte migration
GO:0051647	nucleus localization
GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0055006	cardiac cell development
GO:0055013	cardiac muscle cell development
GO:0060048	cardiac muscle contraction
GO:0061431	cellular response to methionine
GO:0070885	negative regulation of calcineurin-NFAT signaling cascade
GO:0071230	cellular response to amino acid stimulus
GO:0071233	cellular response to L-leucine
GO:0071456	cellular response to hypoxia
GO:0071470	cellular response to osmotic stress
GO:0080135	regulation of cellular response to stress
GO:0090559	regulation of membrane permeability
GO:1900034	regulation of cellular response to heat
GO:1900181	negative regulation of protein localization to nucleus
GO:1901796	regulation of signal transduction by p53 class mediator
GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO:1903691	positive regulation of wound healing, spreading of epidermal cells
GO:1904059	regulation of locomotor rhythm
GO:1904690	positive regulation of cytoplasmic translational initiation
GO:1905672	negative regulation of lysosome organization
GO:1905857	positive regulation of pentose-phosphate shunt
GO:1990253	cellular response to leucine starvation
GO:2000785	regulation of autophagosome assembly

Biological Process

GO:0001558

regulation of cell growth

GO:0002296

T-helper 1 cell lineage commitment

GO:0003007

heart morphogenesis

GO:0003179

heart valve morphogenesis

GO:0006112

energy reserve metabolic process

GO:0006207

'de novo' pyrimidine nucleobase biosynthetic process

GO:0006338

chromatin remodeling

GO:0006468

protein phosphorylation

GO:0006954

inflammatory response

GO:0006974

DNA damage response

GO:0007010

cytoskeleton organization

GO:0007040

lysosome organization

GO:0007281

germ cell development

GO:0007584

response to nutrient

GO:0008361

regulation of cell size

GO:0009267

cellular response to starvation

GO:0009408

response to heat

GO:0009791

post-embryonic development

GO:0010506

regulation of autophagy

GO:0010507

negative regulation of autophagy

GO:0010592

positive regulation of lamellipodium assembly

GO:0010628

positive regulation of gene expression

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO:0010831

positive regulation of myotube differentiation

GO:0016236

macroautophagy

GO:0016241

regulation of macroautophagy

GO:0016242

negative regulation of macroautophagy

GO:0016310

phosphorylation

GO:0018105

peptidyl-serine phosphorylation

GO:0019219

regulation of nucleobase-containing compound metabolic process

GO:0019228

neuronal action potential

GO:0030030

cell projection organization

GO:0030163

protein catabolic process

GO:0030307

positive regulation of cell growth

GO:0030838

positive regulation of actin filament polymerization

GO:0031295

T cell costimulation

GO:0031529

ruffle organization

GO:0031641

regulation of myelination

GO:0031648

protein destabilization

GO:0031667

response to nutrient levels

GO:0031669

cellular response to nutrient levels

GO:0031670

cellular response to nutrient

GO:0031929

TOR signaling

GO:0032868

response to insulin

GO:0032869

cellular response to insulin stimulus

GO:0032956

regulation of actin cytoskeleton organization

GO:0033173

calcineurin-NFAT signaling cascade

GO:0034198

cellular response to amino acid starvation

GO:0035264

multicellular organism growth

GO:0038202

TORC1 signaling

GO:0042752

regulation of circadian rhythm

GO:0043066

negative regulation of apoptotic process

GO:0043200

response to amino acid

GO:0043276

anoikis

GO:0045670

regulation of osteoclast differentiation

GO:0045727

positive regulation of translation

GO:0045792

negative regulation of cell size

GO:0045821

positive regulation of glycolytic process

GO:0045945

positive regulation of transcription by RNA polymerase III

GO:0045948

positive regulation of translational initiation

GO:0046777

protein autophosphorylation

GO:0046889

positive regulation of lipid biosynthetic process

GO:0048266

behavioral response to pain

GO:0048511

rhythmic process

GO:0048709

oligodendrocyte differentiation

GO:0048714

positive regulation of oligodendrocyte differentiation

GO:0048738

cardiac muscle tissue development

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

GO:0050882

voluntary musculoskeletal movement

GO:0051128

regulation of cellular component organization

GO:0051247

positive regulation of protein metabolic process

GO:0051496

positive regulation of stress fiber assembly

GO:0051549

positive regulation of keratinocyte migration

GO:0051647

nucleus localization

GO:0051896

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

GO:0051897

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

GO:0055006

cardiac cell development

GO:0055013

cardiac muscle cell development

GO:0060048

cardiac muscle contraction

GO:0061431

cellular response to methionine

GO:0070885

negative regulation of calcineurin-NFAT signaling cascade

GO:0071230

cellular response to amino acid stimulus

GO:0071233

cellular response to L-leucine

GO:0071456

cellular response to hypoxia

GO:0071470

cellular response to osmotic stress

GO:0080135

regulation of cellular response to stress

GO:0090559

regulation of membrane permeability

GO:1900034

regulation of cellular response to heat

GO:1900181

negative regulation of protein localization to nucleus

GO:1901796

regulation of signal transduction by p53 class mediator

GO:1901838

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

GO:1903691

positive regulation of wound healing, spreading of epidermal cells

GO:1904059

regulation of locomotor rhythm

GO:1904690

positive regulation of cytoplasmic translational initiation

GO:1905672

negative regulation of lysosome organization

GO:1905857

positive regulation of pentose-phosphate shunt

GO:1990253

cellular response to leucine starvation

GO:2000785

regulation of autophagosome assembly

	Cellular Component
GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0016605	PML body
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0031931	TORC1 complex
GO:0031932	TORC2 complex
GO:0045335	phagocytic vesicle

Cellular Component

Golgi membrane

nucleus

nuclear envelope

nucleoplasm

cytoplasm

mitochondrion

mitochondrial outer membrane

GO:0005764

lysosome

GO:0005765

lysosomal membrane

GO:0005783

endoplasmic reticulum

GO:0005789

endoplasmic reticulum membrane

Golgi apparatus

cytosol

endomembrane system

membrane

PML body

dendrite

cytoplasmic vesicle

TORC1 complex

TORC2 complex

phagocytic vesicle

PDB	RCSB:7uxc, PDBe:7uxc, PDBj:7uxc
PDBsum	7uxc
PubMed	36697823
UniProt	P42345\|MTOR_HUMAN Serine/threonine-protein kinase mTOR (Gene Name=MTOR)

Structure of PDB 7uxc Chain A