Structure of PDB 7ux4 Chain A

Receptor sequence
>7ux4A (length=350) Species: 496866 (Thermoanaerobacter pseudethanolicus) [Search protein sequence]
GFAMLSIGKVGWIEKEKPAPGPFDAIVRPLAVAPCTSDIHTVFEGAIGER
HNMILGHEAVGEVVEVGSEVKDFKPGDRVVVPAATPDWRTSEVQRGYHQH
SGGMLAGWKFSNVKDGVFGEFFHVNDADMNLAHLPKEIPLEAAVMIPDMM
TTGFHGAELADIELGATVAVLGIGPVGLMAVAGAKLRGAGRIIAVGSRPV
CVDAAKYYGATDIVNYKDGPIESQIMNLTEGKGVDAAIIAGGNADIMATA
VKIVKPGGTIANVNYFGEGEVLPVPRLEWGCGMAHKTIKGGLCPGGRLRM
ERLIDLVFYKRVDPSKLVTHVFRGFDNIEKAFMLMKDKPKDLIKPVVILA
3D structure
PDB7ux4 Crystallographic snapshots of ternary complexes of thermophilic secondary alcohol dehydrogenase from Thermoanaerobacter pseudoethanolicus reveal the dynamics of ligand exchange and the proton relay network.
ChainA
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.80: isopropanol dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C37 H59 E60 D150 C35 H57 E58 D148
BS02 NAP A D150 T154 G174 I175 G176 P177 V178 R200 G244 V265 N266 Y267 C295 D148 T152 G172 I173 G174 P175 V176 R198 G242 V263 N264 Y265 C293
BS03 NWO A S39 H59 W110 D150 S37 H57 W108 D148
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:7ux4, PDBe:7ux4, PDBj:7ux4
PDBsum7ux4
PubMed35357038
UniProtB0KBL1

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