Structure of PDB 7uw2 Chain A

Receptor sequence
>7uw2A (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
DMPVERILEAELAVEDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQ
VILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFD
RVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVY
ASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPI
DTFLMEMLEA
3D structure
PDB7uw2 Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers.
ChainA
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V280 K284 L294 Q297 V298 R302 T449 F450 E453 V33 K37 L47 Q50 V51 R55 T202 F203 E206
BS02 OI2 A V265 I268 A271 A272 Q275 F313 R316 L326 A327 H435 V18 I21 A24 A25 Q28 F66 R69 L79 A80 H188
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uw2, PDBe:7uw2, PDBj:7uw2
PDBsum7uw2
PubMed36318154
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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