Structure of PDB 7uvm Chain A

Receptor sequence
>7uvmA (length=174) Species: 9606 (Homo sapiens) [Search protein sequence]
IPIVVERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKP
IHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTP
GMRHSLPNSRIMIHQPSAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAM
ERDRYMSPMEAQEFGILDKVLVHP
3D structure
PDB7uvm Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
ChainA
Resolution2.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OX0 A L79 E82 H116 Y118 W146 V148 L15 E18 H52 Y54 W82 V84
BS02 OX0 A L104 S108 Y138 L40 S44 Y74
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7uvm, PDBe:7uvm, PDBj:7uvm
PDBsum7uvm
PubMed36586405
UniProtQ16740|CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (Gene Name=CLPP)

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