Structure of PDB 7uva Chain A

Receptor sequence

>7uvaA (length=329) Species: 10090 (Mus musculus) [Search protein sequence]

RTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLG
IKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEE
EREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTEST
NAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIP
PTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHA
VYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWY
VLERYVYCITNRSHLTKDFQKESLSMDME

3D structure

PDB

7uva Structural basis of paralog-specific KDM2A/B nucleosome recognition.

Chain

Resolution

1.98 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	M111 Q116 I144 S145 N186 A187 I188 Y199 T209 F215 K323 F324 R325	M76 Q81 I109 S110 N151 A152 I153 Y164 T174 F180 K288 F289 R290
BS02	FE	A	H212 D214 H284	H177 D179 H249
BS03	OH0	A	I144 Y199 L201 T209 H212 Y222 K229 H284 V286 N298	I109 Y164 L166 T174 H177 Y187 K194 H249 V251 N263

External links

PDB	RCSB:7uva, PDBe:7uva, PDBj:7uva
PDBsum	7uva
PubMed	36797403
UniProt	P59997\|KDM2A_MOUSE Lysine-specific demethylase 2A (Gene Name=Kdm2a)

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