Structure of PDB 7uv0 Chain A

Receptor sequence
>7uv0A (length=501) Species: 10116 (Rattus norvegicus) [Search protein sequence]
ATFGAWDYGVFATMLLVSTGIGLWVGLAVPVGLSLAASFMSAVQVLGVPA
EAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRA
VRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLY
TTVGGTDVFQVVVMLVGFWVILARGVILLGGPRNVLSLAQQHSRINLMDF
DPDPRSRYTFWTFIVGGTLVWLSMYGVNQAQVQRYVACHTEGKAKLALLV
NQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFE
DLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAPRKLV
FISKGLSFIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLG
MLLPACNTPGVLSGLAAGLAVSLWVAVGATLYPPGEQTMGVLPTSAAGCG
RPALADTFYAISYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWW
D
3D structure
PDB7uv0 Structural insights into the mechanism of the sodium/iodide symporter.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA A Q72 Y144 S416 F417 Q44 Y116 S382 F383
BS02 NA A F67 S69 V71 Q72 Y144 F39 S41 V43 Q44 Y116
Gene Ontology
Molecular Function
GO:0008507 sodium:iodide symporter activity
GO:0015111 iodide transmembrane transporter activity
GO:0015293 symporter activity
GO:0015373 monoatomic anion:sodium symporter activity
GO:0022857 transmembrane transporter activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006590 thyroid hormone generation
GO:0006814 sodium ion transport
GO:0015705 iodide transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071320 cellular response to cAMP
GO:0071371 cellular response to gonadotropin stimulus
GO:0098656 monoatomic anion transmembrane transport
GO:1904200 iodide transmembrane transport
GO:1904322 cellular response to forskolin
GO:1904401 cellular response to Thyroid stimulating hormone
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uv0, PDBe:7uv0, PDBj:7uv0
PDBsum7uv0
PubMed36517601
UniProtQ63008|SC5A5_RAT Sodium/iodide cotransporter (Gene Name=Slc5a5)

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