Structure of PDB 7uux Chain A

Receptor sequence

>7uuxA (length=353) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFNPLSHFLEG
EVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEI
SVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKD
GNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYL
LEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLA
FFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIF
DKL

3D structure

PDB

7uux ATP binds to Cyclic GMP AMP synthase (cGAS) through Mg coordination

Chain

Resolution

2.26 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R158 L159 K160 R161 H203 E386 K395	R10 L11 K12 R13 H55 E232 K241
BS02	dna	A	R161 S165 A168 N196 Y200 Y201 K372	R13 S17 A20 N48 Y52 Y53 K218
BS03	dna	A	K335 T338	K181 T184
BS04	dna	A	R222 K315 G316 R342	R74 K161 G162 R188
BS05	ATP	A	G198 S199 Q211 N213 R364 E371 K402 S420 Y421	G50 S51 Q63 N65 R210 E217 K248 S266 Y267
BS06	MG	A	Q211 N213	Q63 N65
BS07	ZN	A	H378 C384 C385 C392	H224 C230 C231 C238

External links

PDB	RCSB:7uux, PDBe:7uux, PDBj:7uux
PDBsum	7uux
PubMed
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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