Structure of PDB 7uut Chain A

Receptor sequence

>7uutA (length=352) Species: 496866 (Thermoanaerobacter pseudethanolicus) [Search protein sequence]

MKGFAMLSIGKVGWIEKEKPAPGPFDAIVRPLAVAPCTSDIHTVFEGAIG
ERHNMILGHEAVGEVVEVGSEVKDFKPGDRVVVPAATPDWRTSEVQRGYH
QHSGGMLAGWKFSNVKDGVFGEFFHVNDADMNLAHLPKEIPLEAAVMIPD
MMTTGFHGAELADIELGATVAVLGIGPVGLMAVAGAKLRGAGRIIAVGSR
PVCVDAAKYYGATDIVNYKDGPIESQIMNLTEGKGVDAAIIAGGNADIMA
TAVKIVKPGGTIANVNYFGEGEVLPVPRLEWGCGMAHKTIKGGLCPGGRL
RMERLIDLVFYKRVDPSKLVTHVFRGFDNIEKAFMLMKDKPKDLIKPVVI
LA

3D structure

PDB

7uut Crystallographic snapshots of ternary complexes of thermophilic secondary alcohol dehydrogenase from Thermoanaerobacter pseudoethanolicus reveal the dynamics of ligand exchange and the proton relay network.

Chain

Resolution

1.89 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.2: alcohol dehydrogenase (NADP(+)).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	C37 H59 D150	C37 H59 D150
BS02	NAP	A	C37 T38 S39 D150 T154 G174 G176 P177 V178 S199 R200 A242 G243 G244 I248 V265 N266 Y267 C295 K340	C37 T38 S39 D150 T154 G174 G176 P177 V178 S199 R200 A242 G243 G244 I248 V265 N266 Y267 C295 K340
BS03	2RP	A	S39 H59 A85 W110 D150 C295	S39 H59 A85 W110 D150 C295

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0008106	alcohol dehydrogenase (NADP+) activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:7uut, PDBe:7uut, PDBj:7uut
PDBsum	7uut
PubMed	35357038
UniProt	P77990

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