Structure of PDB 7uu4 Chain A

Receptor sequence
>7uu4A (length=373) Species: 9544 (Macaca mulatta) [Search protein sequence]
QIRNMVEPMDPRTFVSNFNNRPILSGLDTVWLCCEVKTKDPSGPPLDAKI
FQGKVYPKAKYHPEMRFLRWFHKWRQLHHDQEYKVTWYVSWSPCTRCANS
VATFLAKDPKVTLTIFVARLYYFWKPDYQQALRILAEAGATMKIMNYNEF
QDCWNKFVDGRGKPFKPWNNLPKHYTLLQATLGELLRHLMDPGTFTSNFN
NKPWVSGQHETYLCYKVERLHNDTWVPLNQHRGFLRNQAPNIHGFPKGRH
AALCFLDLIPFWKLDGQQYRVTCFTSWSPCFSCAQEMAKFISNNEHVSLC
IFAARIYDDQGRYQEGLRTLHRDGAKIAMMNYSEFEYCWDTFVDRQGRPF
QPWDGLDEHSQALSGRLRAILQN
3D structure
PDB7uu4 Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.-
3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R24 I26 L27 S28 V58 Y59 P60 A62 H65 W94 R99 Y124 Y125 F126 W127 Y131 F268 K270 R21 I23 L24 S25 V55 Y56 P57 A59 H62 W91 R96 Y121 Y122 F123 W124 Y128 F261 K263
BS02 ZN A H65 C97 C100 H62 C94 C97
BS03 ZN A H257 C287 C290 H250 C280 C283
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0009972 cytidine deamination
GO:0010526 retrotransposon silencing
GO:0045087 innate immune response
GO:0051607 defense response to virus
GO:0070383 DNA cytosine deamination
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uu4, PDBe:7uu4, PDBj:7uu4
PDBsum7uu4
PubMed36470880
UniProtM1GSK9

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