Structure of PDB 7uu3 Chain A

Receptor sequence
>7uu3A (length=369) Species: 9544 (Macaca mulatta) [Search protein sequence]
MVEPMDPRTFVSNFNNRPILSGLDTVWLCCEVKTKDPSGPPLDAKIFQGK
VYPKAKYHPEMRFLRWFHKWRQLHHDQEYKVTWYVSWSPCTRCANSVATF
LAKDPKVTLTIFVARLYYFWKPDYQQALRILAEAGATMKIMNYNEFQDCW
NKFVDGRGKPFKPWNNLPKHYTLLQATLGELLRHLMDPGTFTSNFNNKPW
VSGQHETYLCYKVERLHNDTWVPLNQHRGFLRNQAPNIHGFPKGRHAALC
FLDLIPFWKLDGQQYRVTCFTSWSPCFSCAQEMAKFISNNEHVSLCIFAA
RIYDDQGRYQEGLRTLHRDGAKIAMMNYSEFEYCWDTFVDRQGRPFQPWD
GLDEHSQALSGRLRAILQN
3D structure
PDB7uu3 Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.
ChainA
Resolution3.099 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.-
3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R24 I26 L27 S28 Y59 W94 Y124 Y125 W127 N176 K270 R17 I19 L20 S21 Y52 W87 Y117 Y118 W120 N165 K259
BS02 ZN A H65 C97 C100 H58 C90 C93
BS03 ZN A H257 C287 C290 H246 C276 C279
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0009972 cytidine deamination
GO:0010526 retrotransposon silencing
GO:0045087 innate immune response
GO:0051607 defense response to virus
GO:0070383 DNA cytosine deamination
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uu3, PDBe:7uu3, PDBj:7uu3
PDBsum7uu3
PubMed36470880
UniProtM1GSK9

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