Structure of PDB 7usw Chain A

Receptor sequence
>7uswA (length=608) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
TRQALLERIRQKKEVIGKLRCQAWSMTRKRRTLKLAQKYLEQHESKVSRS
HLYMEEMRKRARLMKRSFSNFKTYLIPWESKIKRIESHFGSVVSSYFTFL
RWIVFVNIMITLIALVFVVLPETLADSVANEGRFNRTKTRKQIPANERVH
ADELAVVWHYDGYLRYSPLFYGYYSDDPFLGNKIKYALPLAYFMVTLTIF
AYSFFAILRKMAANARMSKLSGSKAEQYIFNWKLFTGWDYTIGNSETASN
TVMAVVIKLRESIADIKKDAHGKFRLLQFSLRVFANIIICAMLGFSIYCI
IFAVQKSQVQDDGNLFTKNQVPSVVSTITHVFPMIFDLIGKMENYHPRTA
LRAHLGRVLILYTVNYITLIFALFEKMTALRDRVNNDICWETIIGQEIVK
LVTMDLIFTILSILVIDLFRGLWIKYCSSWWCWDIETTFPEYGEFKVAEN
VLHIINNQGMIWLGLFFAPLLPAINNIKLIILMYIRGWAVMTCNVPAREI
FRASRSSNFYLGILLIWLLLCTLPVGFVIASMSPSRSCGPFARYQHFYTV
VTREIEKRVDQTVLSYIRHIASPGVVIPIILFLILIIYFLFSLVRGLREA
NTDLQAQL
3D structure
PDB7usw Structures of the TMC-1 complex illuminate mechanosensory transduction.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D695 F723 D417 F445
BS02 CLR A F191 Y260 M268 F117 Y186 M194
BS03 ZFC A S784 N786 S506 N508
BS04 ZFC A I441 F445 F448 F805 I367 F371 F374 F527
BS05 ZFC A M183 I187 Y276 M109 I113 Y202
BS06 ZFC A F191 I258 F117 I184
BS07 ZFC A R426 S782 R352 S504
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005272 sodium channel activity
GO:0008381 mechanosensitive monoatomic ion channel activity
Biological Process
GO:0007606 sensory perception of chemical stimulus
GO:0034220 monoatomic ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0050906 detection of stimulus involved in sensory perception
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043025 neuronal cell body
GO:0097730 non-motile cilium

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Molecular Function
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Cellular Component
External links
PDB RCSB:7usw, PDBe:7usw, PDBj:7usw
PDBsum7usw
PubMed36224384
UniProtD3KZG3|TMC1_CAEEL Transmembrane channel-like protein 1 (Gene Name=tmc-1)

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