Structure of PDB 7urf Chain A

Receptor sequence

>7urfA (length=491) Species: 9606 (Homo sapiens) [Search protein sequence]

MLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGG
LKKDATDFEWSFWMEWGKQWLVWLLLGHMVVSQMATLLARKHRPWILMLY
GMWACWCVLGTPGVAMVLLHTTISFCVAQFRSQLLTWLCSLLLLSTLRLQ
GVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQQLPAASTSYS
FPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLALGLGR
LLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLGGLALAQVLFFYVKY
LVLFGVPALLMRLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHNFLIRYV
YIPVGGSQHGLLGTLFSTAMTFAFVSYWCGGYDYLWCWAALNWLGVTVEN
GVRRLVETPCIQDSLARYFSPQARRRFHAALASCSTSMLILSNLVFLGGN
EVGKTYWNRIFIQGWPWVTLSVLGFLYCYSHVGIAWAQTYA

3D structure

PDB

7urf Mechanisms and inhibition of Porcupine-mediated Wnt acylation.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	F58 Y167 Y300 D339 C379	F58 Y167 Y300 D339 C379
BS02	HEM	A	L15 H18 R250 W254 Y297 C324 S326 T327	L15 H18 R250 W254 Y297 C324 S326 T327
BS03	PKZ	A	F296 V325 M334 W335 R336 L342 H343 I347 Y351 I352 G356 S357 Q358 F372 V375 W388 L439 I440 N443 F446 Y479	F296 V325 M334 W335 R336 L342 H343 I347 Y351 I352 G356 S357 Q358 F372 V375 W388 L439 I440 N443 F446 Y479
BS04	PKZ	A	F17 W283	F17 W283
BS05	AJP	A	F48 G49 L51	F48 G49 L51
BS06	AJP	A	Y23 Y26 L264	Y23 Y26 L264
BS07	AJP	A	F19 Y23	F19 Y23
BS08	AJP	A	Y20 W283	Y20 W283
BS09	AJP	A	M438 W457 F461 W465	M438 W457 F461 W465

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008374	O-acyltransferase activity
GO:0016409	palmitoyltransferase activity
GO:0016746	acyltransferase activity

	Biological Process
GO:0007224	smoothened signaling pathway
GO:0018009	N-terminal peptidyl-L-cysteine N-palmitoylation

	Cellular Component
GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7urf, PDBe:7urf, PDBj:7urf
PDBsum	7urf
PubMed	35831507
UniProt	Q5VTY9\|HHAT_HUMAN Protein-cysteine N-palmitoyltransferase HHAT (Gene Name=HHAT)

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