Structure of PDB 7ure Chain A

Receptor sequence
>7ureA (length=432) Species: 9606 (Homo sapiens) [Search protein sequence]
FSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKH
ASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTI
LIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPV
EFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSCRWLQKVARSLALALLC
LVLSTCVGPYLFPYFIPLNARWLRAYESAVSFHFSNYFVGFLSEATATLA
GAGFTEEKDHLEWDLTVSKPLNVELPRSMVEVVTSWNLPMSYWLNNYVFK
NALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLA
RILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDV
YGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
3D structure
PDB7ure Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
ChainA
Resolution3.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.250: [Wnt protein] O-palmitoleoyl transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A C17 Q24 Q28 F68 H121 K122 I129 F167 L204 Y213 S249 V253 C14 Q21 Q25 F65 H118 K119 I126 F164 L201 Y210 S235 V239
BS02 AJP A S100 I103 N315 A331 S97 I100 N301 A317
BS03 ZN A C376 H382 C362 H368
Gene Ontology
Molecular Function
GO:0016746 acyltransferase activity
GO:0017147 Wnt-protein binding
GO:1990698 palmitoleoyltransferase activity
Biological Process
GO:0006497 protein lipidation
GO:0009100 glycoprotein metabolic process
GO:0016055 Wnt signaling pathway
GO:0030258 lipid modification
GO:0045234 protein palmitoleylation
GO:0061355 Wnt protein secretion
GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0032281 AMPA glutamate receptor complex
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ure, PDBe:7ure, PDBj:7ure
PDBsum7ure
PubMed35831507
UniProtQ9H237|PORCN_HUMAN Protein-serine O-palmitoleoyltransferase porcupine (Gene Name=PORCN)

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