Structure of PDB 7uqk Chain A

Receptor sequence
>7uqkA (length=576) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
NVNFDDIGGLDNYIDQLKEMVALPLLYPELYQNFNITPPRGVLFHGPPGT
GKTLMARALAASCSSDERKITFFMRKGADILSKWVGEAERQLRLLFEEAK
KHQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMDNRGQVIVI
GATNRPDAVDPALRRPGRFDREFYFPLPDVKARFKILQIQTRKWSSPLST
NFIDKLAFLTKGYGGADLRSLCTEAALISIQRSFPQIYRSNDKLLVDPSK
IKVKVSDFMLALKKIVPSSARSTGSSPQPLPELIKPLLADQLNNLKNKLD
YMLNIKDTTFQRNTSLLQNFIDYEEYSSFRSYEFFESMAESQICKPRLLI
NGPKGNGQQYVGAAILNYLEEFNVQNLDLASLVSESSRTIEAAVVQSFME
AKKRQPSVVFIPNLDIWINTIPENVILVLSGLFRSLQSNEKILLLCLAEN
LDISEVKNGILSDFAFDKNIFQLHKPSKENITRYFSNLIELLKTKPSDIP
MKKRRVKPLPELQKVKELILTPEQIKKVSACLIEHCQNFTVSQLEDVHSS
VAKIIWKSKSAWDKTGTVDEIIKFLS
3D structure
PDB7uqk The Saccharomyces cerevisiae Yta7 ATPase hexamer contains a unique bromodomain tier that functions in nucleosome disassembly.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G417 G458 T459 G460 K461 T462 L463 I595 G624 R628 G8 G49 T50 G51 K52 T53 L54 I186 G215 R219
BS02 ADP A M550 R574 M141 R165
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042393 histone binding
GO:0140658 ATP-dependent chromatin remodeler activity
GO:0140674 ATP-dependent histone chaperone activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006261 DNA-templated DNA replication
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0034080 CENP-A containing chromatin assembly
GO:0045815 transcription initiation-coupled chromatin remodeling
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:2000219 positive regulation of invasive growth in response to glucose limitation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uqk, PDBe:7uqk, PDBj:7uqk
PDBsum7uqk
PubMed36592926
UniProtP40340|ATAD2_YEAST ATPase histone chaperone YTA7 (Gene Name=YTA7)

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