Structure of PDB 7upg Chain A

Receptor sequence
>7upgA (length=75) Species: 9606 (Homo sapiens) [Search protein sequence]
SVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKI
GSLDNITHVPGGGNKKIETHKLTFR
3D structure
PDB7upg Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.
ChainA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KDH A E338 K340 E34 K36
BS02 KDH A N327 H329 N23 H25
Gene Ontology
Molecular Function
GO:0008017 microtubule binding
GO:0015631 tubulin binding

View graph for
Molecular Function
External links
PDB RCSB:7upg, PDBe:7upg, PDBj:7upg
PDBsum7upg
PubMed36114178
UniProtP10636|TAU_HUMAN Microtubule-associated protein tau (Gene Name=MAPT)

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