Structure of PDB 7up2 Chain A

Receptor sequence
>7up2A (length=230) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
EYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELL
LIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGV
ATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHST
DNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYP
EAEVVIPGHGLPGGLDLLQHTANVVKAHKN
3D structure
PDB7up2 Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
ChainA
Resolution1.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H114 H116 H179 H83 H85 H148
BS02 ZN A D118 C198 H240 D87 C167 H209
BS03 NZR A F62 Y67 W87 H116 D118 H179 C198 G209 N210 H240 F31 Y36 W56 H85 D87 H148 C167 G178 N179 H209
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7up2, PDBe:7up2, PDBj:7up2
PDBsum7up2
PubMed36475645
UniProtQ9XAY4

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