Structure of PDB 7uoq Chain A

Receptor sequence
>7uoqA (length=140) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAG
RWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEDGGVIESMNKELKKIIGQ
VRDQAEHLKTAVQMAVFIHNHKRKGYSAGERIVDIIATDI
3D structure
PDB7uoq Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
ChainA
Resolution1.8867 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O20 A Q95 T124 K127 A128 Q39 T68 K71 A72
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:7uoq, PDBe:7uoq, PDBj:7uoq
PDBsum7uoq
PubMed35707159
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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