Structure of PDB 7umy Chain A

Receptor sequence
>7umyA (length=259) Species: 575584 (Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841) [Search protein sequence]
GLLAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDEF
AEQFGSKLVFPCDVAVDAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTLD
GDFTDVTDRDGFKIAHDISAYSFVAMARAAKPLLQARQGCLLTLTYQGSE
RVMPNYNVMGMAKASLEAGVRYLASSLGVDGIRVNAISAGPIRTLAASGI
KSFRKMLDANEKVAPLKRNVTIEEVGNAALFLCSPWASGITGEILYVDAG
FNTVGMSQS
3D structure
PDB7umy An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections
ChainA
Resolution2.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G15 A17 S21 I22 P42 D66 V67 S93 I94 G95 L147 T148 Y149 K166 A192 P194 I195 T197 A199 G12 A14 S18 I19 P39 D63 V64 S90 I91 G92 L144 T145 Y146 K163 A189 P191 I192 T194 A196
BS02 NUC A F96 A97 A99 L102 N158 Y159 A199 I203 F93 A94 A96 L99 N155 Y156 A196 I200
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7umy, PDBe:7umy, PDBj:7umy
PDBsum7umy
PubMed36188352
UniProtD0CAD5

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