Structure of PDB 7um6 Chain A

Receptor sequence
>7um6A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
GVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLV
AALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDR
YWSITRPMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGEECQVSREP
SYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVWREQKEQRAALMVGILI
GVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAF
NKNYNSAF
3D structure
PDB7um6 Inactive and active state structures template selective tools for the human 5-HT 5A receptor.
ChainA
Resolution2.79 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H8G A W117 D121 C125 S204 F301 W78 D82 C86 S156 F210
Gene Ontology
Molecular Function
GO:0001586 Gi/o-coupled serotonin receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0030594 neurotransmitter receptor activity
GO:0051378 serotonin binding
GO:0099589 serotonin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0021766 hippocampus development
GO:0032355 response to estradiol
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0043204 perikaryon
GO:0099634 postsynaptic specialization membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7um6, PDBe:7um6, PDBj:7um6
PDBsum7um6
PubMed35835867
UniProtP47898|5HT5A_HUMAN 5-hydroxytryptamine receptor 5A (Gene Name=HTR5A)

[Back to BioLiP]