Structure of PDB 7um5 Chain A

Receptor sequence
>7um5A (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
GVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLV
AALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDR
YWSITRPMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGS
EECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVEQKEQRAA
LMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFN
PLIYTAFNKNYNSAFKNF
3D structure
PDB7um5 Inactive and active state structures template selective tools for the human 5-HT 5A receptor.
ChainA
Resolution2.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8K3 A D121 C125 S204 E305 D82 C86 S165 E221
Gene Ontology
Molecular Function
GO:0001586 Gi/o-coupled serotonin receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0030594 neurotransmitter receptor activity
GO:0051378 serotonin binding
GO:0099589 serotonin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0021766 hippocampus development
GO:0032355 response to estradiol
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0043204 perikaryon
GO:0099634 postsynaptic specialization membrane

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Cellular Component
External links
PDB RCSB:7um5, PDBe:7um5, PDBj:7um5
PDBsum7um5
PubMed35835867
UniProtP47898|5HT5A_HUMAN 5-hydroxytryptamine receptor 5A (Gene Name=HTR5A)

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