Structure of PDB 7ukv Chain A

Receptor sequence
>7ukvA (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
GEAPNQALLRILKETEFKKIKVLGSGGTVYKGLWIPEGEKVKIPVAIKES
PKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYV
REHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVK
ITDFGLAKLLGAEYHAKVPIKWMALESILHRIYTHQSDVWSYGVTVWELM
TFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSR
PKFRELIIEFSKMARDPQRYLVIQGDEDMDDVVDADEYLI
3D structure
PDB7ukv Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZRT A L718 A743 K745 E762 M793 P794 G796 C797 L844 D855 L23 A46 K48 E60 M91 P92 G94 C95 L142 D153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ukv, PDBe:7ukv, PDBj:7ukv
PDBsum7ukv
PubMed36518696
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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