Structure of PDB 7ujt Chain A

Receptor sequence

>7ujtA (length=268) Species: 9606 (Homo sapiens)

TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY
YSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLAD
FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL
LVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
SKRITAAEALKHPWISHR

3D structure

• PDB: 7ujt CaMKII binds both substrates and activators at the active site.
• Chain: A
• Resolution: 2.1 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.17: calcium/calmodulin-dependent protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	R52 E96 F98 N135 K137 E139 L159 F173 A174 G175 T176 G178 G209 Y210 P211 P212 W214 Q218 H219 E236	R46 E90 F92 N129 K131 E133 L153 F167 A168 G169 T170 G172 G203 Y204 P205 P206 W208 Q212 H213 E230
BS02	ATP	A	G20 G22 S25 V27 A40 K42 V92	G14 G16 S19 V21 A34 K36 V86

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:7ujt, PDBe:7ujt, PDBj:7ujt
• PDBsum: 7ujt
• PubMed: 35830796
• UniProt: Q9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)