Structure of PDB 7ujs Chain A

Receptor sequence
>7ujsA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY
YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLAD
FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL
LVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
SKRITAAEALKHPWISHR
3D structure
PDB7ujs CaMKII binds both substrates and activators at the active site.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R52 K56 E96 F98 D135 K137 E139 L159 F173 G175 T176 G178 Y179 Y210 P211 W214 Q218 H219 S234 E236 R46 K50 E90 F92 D129 K131 E133 L153 F167 G169 T170 G172 Y173 Y204 P205 W208 Q212 H213 S228 E230
BS02 ADP A K21 V27 A40 K42 V92 D156 K15 V21 A34 K36 V86 D150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ujs, PDBe:7ujs, PDBj:7ujs
PDBsum7ujs
PubMed35830796
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

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